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Re: Are MAOIs worth it? » tensor

Posted by Quintal on January 3, 2007, at 9:56:11

In reply to Re: Are MAOIs worth it? » Quintal, posted by tensor on January 3, 2007, at 6:07:57

>How does selegiline (the oral version) compare to Nardil and Parnate? It works more on dopamine and is used for Parkinson's disease but that's all I know. It's also the only MAOI that can be prescripted here without a licence.

Selegiline felt nothing like Parnate, Marplan and moclobemide to me. It is a selective MAO-B inhibitor at doses <20mg and MAO-B has little effect on the breakdown of serotonin and nordrenaline, having more action on dopamine and phenethylamine. Generally speaking the non-selective irreversible MAOIs like Nardil, Parnate and Marplan have a much broader action across the range of neurotransmitters. Selegiline is worth trying as a first line MAOI but non-selective MAOIs are still definitely worth trying if you have a poor response to oral selegiline.

Q


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