Posted by linkadge on December 8, 2006, at 8:45:15
In reply to Re: Pindolol: talked about, never used., posted by psychobot5000 on December 7, 2006, at 22:07:30
I think there is more convincing evidence that there is dysfunction of serotonin autoreceptors than there is of altered uptake or MAO function.
ECT for instance alters autoreceptor function without affecting serotonin uptake etc. As supposedly does rTMS.ALso, I remember reading that some uptake inhibitors paxil, fluoxetine, but others citalopram, sertraline led to a downregulation of autoreceptors.
Some new drugs are serotonin 1a/1b autoreceptor antagonists. Supersensitivity of both 1a and 1b autoreceptors exist in depression, and the two controll serotonin release in discrete brain regions.
I have always wondered what a combination of lithium and pindolol would do. Lithium is a 5-ht1b autoreceptor antagonist and pindolol a 5-ht1a autoreceptor antagonist.
Linkadge
poster:linkadge
thread:711297
URL: http://www.dr-bob.org/babble/20061206/msgs/711438.html