Posted by Edwin Ransom on August 8, 2006, at 12:46:54
In reply to Re: EMSAM and Inositol, posted by SLS on August 8, 2006, at 6:24:10
Sorry about the link:
This is just the study in which the Israelis discovered that inositol had SSRI-like effects.
My logic follows this pattern:
1.) Serotonin syndrome will happen if you have too much serotonin in your brain.
2.) SSRIs increase the amount of serotonin in your brain.
3.) Inositol effects behavior the way an SSRI would, so it increases the amount of serotonin in your brain
4.) SSRIs combined with MAOIs cause you to have too much serotonin in your brain.
5.) Inositol combined with a MAOI may cause serotonin syndrome.
The weak step is 3.), I am wondering if inositol might have a completely different mechanism of action from the SSRIs. I know that people have reasoned from the low side-effect profile of inositol to the conclusion that inositol is very selective and therefore less of a risk. But this doesn't seem conclusive: it may be selective, but still work on the subdomain of serotonin receptors that cause the syndrome.
I just don't know anything about neurophysiology.
It would be great if inositol and Emsam could be safely combined. It sounds like a lot of people who take Emsam for depression still have anxiety problems.
poster:Edwin Ransom
thread:674658
URL: http://www.dr-bob.org/babble/20060802/msgs/674899.html