Posted by linkadge on August 7, 2006, at 21:25:11
In reply to Re: Ketamine used to treat depression - NIMH » SLS, posted by JahL on August 7, 2006, at 21:08:44
Its all about the 'pleasure principle'. Pleasure and depression just don't mix, they are like oil and water.
Even the meagre antdiepressant effects of the SSRI's and TCA's are dependant on an upregulation of receptors sites involved in hedonic capacity. A couple of studies have shown that for most recovered antidepressant users, a d2 antagonist will abolish the clinical effect.
It is only when you increase hedonic capacity that people will report feeling any better.
Doctors want this silver bullit that just doesn't exist.
I say, if you find something that can sustainably help depression, then who cares if it causes mood improvement in normal people, who cares if a deeply depressed person feels slightly euphoric.
Linkadge
poster:linkadge
thread:674656
URL: http://www.dr-bob.org/babble/20060802/msgs/674687.html