Posted by SLS on August 7, 2006, at 20:21:07
In reply to Ketamine used to treat depression - NIMH, posted by SLS on August 7, 2006, at 20:02:08
These same investigators found that memantine, another NMDA receptor antagonist, was ineffective in treating depression. This was my experience as well, although I did experience a brief mild improvement early in treatment at 20mg/day. I don't know what differentiates ketamine from memantine pharmacologically.
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: Am J Psychiatry. 2006 Jan;163(1):153-5. Related Articles, Links
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A double-blind, placebo-controlled study of memantine in the treatment of major depression.Zarate CA Jr, Singh JB, Quiroz JA, De Jesus G, Denicoff KK, Luckenbaugh DA, Manji HK, Charney DS.
Mood and Anxiety Disorders Program, National Institute of Mental Health, Department of Human Health Services, Bethesda, MD, USA. zaratec@mail.nih.gov
OBJECTIVE: This study was designed to assess possible antidepressant effects of memantine, a selective N-methyl-D-aspartate (NMDA) receptor antagonist in humans. METHOD: In a double-blind, placebo-controlled study, 32 subjects with major depression were randomly assigned to receive memantine (5-20 mg/day) (N=16) or placebo (N=16) for 8 weeks. Primary efficacy was assessed by performance on the Montgomery-Asberg Depression Rating Scale (MADRS). RESULTS: The linear mixed models for total MADRS scores showed no treatment effect. CONCLUSIONS: In an 8-week trial, the low-to-moderate-affinity NMDA antagonist memantine in doses of 5-20 mg/day was not effective in the treatment of major depressive disorder.
poster:SLS
thread:674656
URL: http://www.dr-bob.org/babble/20060802/msgs/674661.html