Posted by Cairo on August 5, 2006, at 8:05:40
Variation in 5-HT2a receptors may be more important than whether you are a slow metabolizer in causing adverse drug reactions, according to this article:
http://ajp.psychiatryonline.org/cgi/content/full/160/10/1830
I can never get to therapeutic doses of SSRIs due to severe adverse reactions, I get so many cognitive side effects that I cannot function with other meds such as amitriptyline, nortriptyline, and meds such as Effexor or Cymbalta cause elevated blood pressure, anxiety, etc. Giving other meds to counteract these side effects cause problems of their own.
What is the practical use of the information in the article? Would genotyping be useful at all and could it be used to select certain meds that block the 5-HT2a receptor? On the other hand, Topamax, which I don't believe affects the 5-HT2a receptor at all, caused so many severe side effects that I am still reeling from the side effects it induced over a year ago. Lyrica causes noticeable unsteadiness if I increase the dose to counter dosage tolerance and weight gain is a major issue with it.
HOW DOES ONE CHOOSE MEDS WHEN YOU GET SO MANY SIDE EFFECTS? I feel spacey all the time and it is affecting my day to day functioning, especially driving. I think I need CRH augmentation, but Wellbutrin and anything else that is stimulating exacerbate the panic attacks and anxiety (as do caffeine and chocolate). Exercise is tricky as it makes my myofascial problems worse.
Cairo
poster:Cairo
thread:673918
URL: http://www.dr-bob.org/babble/20060802/msgs/673918.html