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Re: Meds and pregnancy (not me)

Posted by SLS on August 5, 2006, at 8:03:55

In reply to Re: Meds and pregnancy (not me) » Racer, posted by Phillipa on August 4, 2006, at 11:22:02

"The clinical presentation of fluoxetine withdrawal depends on the timing and amount of last maternal use, maternal and infant metabolism and excretion. The most commonly reported neonatal symptoms include agitation, irritability, impending seizures, hypertonia or hypotonia, hyperreflexia, drowsiness, jitteriness, feeding problems, persistent crying, tachypnoea, temperature instability, acrocyanosis and tremors. In addition fluoxetine toxicity has been observed as scattered petechiae over the face and trunk along with cephalhaematoma(5), marked motor automatism and skin manifestations(6). It has also been associated with colic(3), lipomeningocele(4), and cardiac arrhythmia(7). Due to its longer half life (2-3 days) the withdrawal symptoms due to fluoxetine are usually mild and self limiting compared to other SSRI’s. Moreover it is obvious from the published work that majority of the reported cases of suspected SSRI-induced neonatal withdrawal syndrome are due to Paroxetine and fluoxetine(9)."

http://www.indianpediatrics.net/jan2006/jan-66-69.htm

 

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