Posted by linkadge on August 22, 2005, at 20:20:35
In reply to Re: SSRI use in children *might* affect development » ed_uk, posted by ixus on August 22, 2005, at 18:35:06
Interesting. I think that a lot of the information to push antidepressants is flawed.
For instance my doctor told me that the SSRI's will prevenent stress and depression induced hippocampal shrinkage.
The problem is this. This has never been proven conclusivly in humans or rats. One of the main studies showed that Tianaptine and clompiramine showed moderate hippocampal sparing effects, but that fluoxetine showed no such effect. Critics said that these results were being extended to SSRI's without any proof at all.
TCA's and Tianeptine probably have a more marked effect on HPA axis normalization than SSRI's.
I've actually read many studies that show the opposite, that SSRI's increase cortisol.
I think this is why TCA's may poop out less.Linkadge
poster:linkadge
thread:545253
URL: http://www.dr-bob.org/babble/20050821/msgs/545342.html