Posted by Franz on August 21, 2005, at 8:21:07
In reply to Re: Psychiatric and Associated Drugs chart -SLS, posted by SLS on August 20, 2005, at 21:23:40
> > Hello SLS and everyone reading,
> >
> > Could you please explain in your Psychiatric and Associated Drugs chart (which is very helpful)
> > http://sl.schofield3.home.att.net/medicine/psychiatric_drugs_chart.html
> >
> > which is the difference between 5-HT release (alprazolam) and 5-HT increase (clonazepam)?.
>
> Sometimes, science has not reached the point at which absolute understanding prevails. The best that I could glean from the literature at the time I put the chart together is that clonazepam somehow potentiated serotonergic neurotransmission and/or increased 5-HT content, but that the mechanism by which this occurs remained obscure. Some investigations actually report the reverse with clonazepam, wherein synaptic concentration is decreased while postsynaptic 5-HT1a receptors are downregulated. This might help explain why some people experience depression when taking clonazepam, but not other BZDs.
>
>
> - ScottThanks Scott
I have tried both and alprazolam has a more positive effect on mood for me, maybe this is the explanation?.
poster:Franz
thread:544407
URL: http://www.dr-bob.org/babble/20050821/msgs/544689.html