Posted by neo on March 27, 2005, at 7:21:39
Lot of Ad lead to tolerance. The developing of tolerance seem to reduce or vanish the effect of the subsatance.
In particular the dopaminergic substances seems always to develop quick tolerance and quick vanish the pro-dopaminergic effect of the drug.
In particular Amisulpride (as i read in this board and from my experience) develop tolerance within 1-2 days as synapthic cells recognize the dopaminergic effect and rise its level of sensitivity to the drug. So the dopaminergic effect will be drammatically reduced.
That's the why i stay well on Amisulpride or Sulpiride for about 36 h than all right effects vanish and no help i receive from continuing in assumption of the drug.
So, how to counteract this damned tolerance?
Every counseil and idea will be appriciate!
I have a theory:
The tolence response seems to be co-related to the quantity of the drug. The more i assume, the more tolerance is high. Nothing i could say about the speed of develop tolerance in relation of the quantity of substance.
But what about try with subtherapeutic dosage?
For example 6 mg of amisulpride (1/8) of the normal dosage. If my theory is right the tolerance could not to be developed (or developed in less strength) cause the cells do not recognize and do not response to the compound?
You could say that the quantity of drug is not enough to have a therapeutic effect! That's true, I think! But i think that we could try to begin with low dosage, than, when the cells recognize the drug as normal, probably will not develop tolerance for higher dosage anymore.
Just a little idea, but your share, theory and experience will be greatly appreciate!
Thanks you all!!!!
Neo
poster:neo
thread:476151
URL: http://www.dr-bob.org/babble/20050326/msgs/476151.html