Posted by corafree on October 18, 2004, at 1:16:46
In reply to Re: Effexor XR Metabolization » dancingstar, posted by corafree on October 17, 2004, at 22:16:17
I'm following up myself here.
A few months back I did some research on metabolization, posted it, and, found above. It is as follows:
I'm talking about Effexor here.
Yes, I am having success with it, after a bit of changing the dosage regimen. Upon first starting, I took my initial 75mg upon waking and took a followup of 37.5 at bedtime. I was experiencing side effects, mainly anxiety, from around 4-5p until bedtime.
I now take the follow-up dose of 37.5mg approx. 5 hours after taking my waking dose, and have virtually no anxiety or side effects, and it lasts all day! I can truly say it is the best drug I have ever been on, and I've been on all the SSRIs.
I am what is called a 'POOR METABOLIZER'.
Many factors go into the pharmacokinetics of a drug, making the dosage regimen individual to individuals.
There are EXTENSIVE METABOLIZERS (normal metabolizers) and, like me, POOR METABOLIZERS.
Some factors which go into deciding which you are, are: 1) hepatic drug clearance (low intrinsic clearance - the effect can be increased by giving a second liver enzyme boosting agent, and hepatic blood flow - how much is initially gobbled up by the liver, because the slower the flow, the higher the extraction, and vice-versa; 2) protein binding (drugs get stuck and can't go anywhere); and 3) ionization (highly ionized drugs cannot cross lipid membranes and basically can't go anywhere.)
So, dosage regimens should depend upon whether you are a slow metabolizer or an extensive (normal) metabolizer.
It took me a while to realize I was a slow metabolizer and that I would actually need more of a drug.
(p.s. since then have increased Eff-XR dosage)
BWishes CF
> DANCING STAR,
>
> I just wrote you a very lengthy post in response to your post and it got LOST IN SPACE!
>
> Give me some time and I'll re-write.
>
> Thank you so much for, well, explaining your interpretation of slow vs normal metabolization. I welcome fresh and differing understandings, to help be better educated, as sometimes we must be our own healers.
>
> I'll be back w/ ya' Best Wishes CF
poster:corafree
thread:13781
URL: http://www.dr-bob.org/babble/20041012/msgs/404317.html