Posted by chemist on June 29, 2004, at 2:05:02
In reply to Re: why are benzo's considered superior?, posted by 1980Monroe on June 28, 2004, at 21:41:22
> despite the toxity, does "superior" just mean overall better in general effects?
>
> Chemist, this should be a breeze to you so you tell if im wrong, but i belive barbitureates work by opening calcium ion channels, which is maybe why they bring more sedating action than the benzodiazpenines, which only enhance GABA actity but have do not directly effect the ion channels. They both have their specific receptor on the GABA receptors, which the barbiturate receptor are in the inner ring of the channels and is why they open them, benzo's are on the outer top part and dont manipulate the opening, maybe thats why there not toxic.,
>
> i heard barbiturates actualyl can act as GABA at high doses which is intresting.
>
> But if there more sedating, than why are not considered superior?
>
> Matthi there, chemist here... barbituates are not indicated in GABA neuroransmission, rather in the cortex.....reagardless of the dosoe, very different mechanism. not GABAnergeic activity....all the best, chemist
poster:chemist
thread:361064
URL: http://www.dr-bob.org/babble/20040627/msgs/361549.html