Posted by Rick on June 27, 2004, at 19:08:22
In reply to Re: Provogil/Adrafinil - Take long to start working ?, posted by zuzu80 on June 27, 2004, at 12:06:33
> Not sure if it's fine to take them together. Adrafinil has direct effect on noradrenergic system and indirect one on dopamine.
Not sure about adrafinil, but here is what the most current Provigil monograph says about its dopminergic and adrenergic activity (or lack thereof):
Modafinil is not a direct- or indirect-acting dopamine receptor agonist and is inactive in several in vivo preclinical models capable of detecting enhanced dopaminergic activity. In vitro, modafinil binds to the dopamine reuptake site and causes an increase in extracellular dopamine, but no increase in dopamine release. In a preclinical model, the wakefulness induced by amphetamine, but not modafinil, is antagonized by the dopamine receptor antagonist haloperidol.
Modafinil does not appear to be a direct or indirect alpha-adrenergic agonist. Although modafinil-induced wakefulness can be attenuated by the a1pha-adrenergic receptor antagonist, prazosin, in assay systems known to be responsive to a1pha-adrenergic agonists, modafinil has no activity.
I think the early view that Provigil acts primarily as an adrenergic agonist is still widely cited even though it has apparently been shown to be untrue.
Rick
poster:Rick
thread:360436
URL: http://www.dr-bob.org/babble/20040627/msgs/361078.html