Posted by Sad Panda on March 28, 2004, at 22:46:17
In reply to IMIPRAMINE? AT WHAT DOSE DOES NE REUPTAKE OCCUR??, posted by aazospiro on March 28, 2004, at 13:00:39
> I read somewhere that a considerable amount of imipramine is metabolized to desipramine on first pass. Can NE reuptake occur at low doses? Example 12.5 mg? The reason I asked is that it seems to calm me down quite abit without ANY drowsiness. But its a stimulated calmness. I was VERY surprised because amitriptyline made me very very drowsy and heavy. ANYONE KNOW OF ANY SITES WITH DIFINATIVEINFORMATION ON THE FUNDAMENTAL DIFFERENCES ON THESE TRICYCLIC AGENTS?
>
>Here is a table I made with data from http://www.psychotropical.com/
_______________5-HT__NE____H1___5-HT2A__A1___M1
CLOMIPRAMINE__0.28__38____15____23_____50___25
IMIPRAMINE_____1.4___37____37____150____32___60
AMITRIPTYLINE__4.3___35____1_____18_____24___13
DOTHIEPIN______8.6___46____3.6__________450__38
NORTRIPTYLINE_18____4.3___6.3___41_____55___50
DESIPRAMINE_________0.83__60____350____100__210
DOXEPIN________68____29.5__0.2___27_____23___52
MIANSERIN______4000________0.4__________34_____
MIRTAZAPINE________________0.12__30____________
NEFAZODONE____200_________24000_26_____48_____
VENLAFAXINE____8.9___1060__35000________35000__
PAROXETINE_____0.13__40______________________80
SERTRALINE_____0.29________24000________380__1300
FLUOXETINE_____0.81__240_________280_________1000
CITALOPRAM_____1.16____________________________
FLUVOXAMINE____2.2_____________________________Imipramine is a very weak H1 blocker, Ami is strong. Sorry the table is hard to read, this board doesn't allow for tabs or spaces.
Cheers,
Panda.
poster:Sad Panda
thread:329473
URL: http://www.dr-bob.org/babble/20040325/msgs/329668.html