Posted by King Vultan on March 28, 2004, at 16:21:51
In reply to IMIPRAMINE? AT WHAT DOSE DOES NE REUPTAKE OCCUR??, posted by aazospiro on March 28, 2004, at 13:00:39
> I read somewhere that a considerable amount of imipramine is metabolized to desipramine on first pass. Can NE reuptake occur at low doses? Example 12.5 mg? The reason I asked is that it seems to calm me down quite abit without ANY drowsiness. But its a stimulated calmness. I was VERY surprised because amitriptyline made me very very drowsy and heavy. ANYONE KNOW OF ANY SITES WITH DIFINATIVEINFORMATION ON THE FUNDAMENTAL DIFFERENCES ON THESE TRICYCLIC AGENTS?
NE reuptake blockade occurs at low dosages without even considering the activity of the desipramine metabolite. Imipramine is the essence of a "dirty" drug and binds to multiple sites of action nearly simultaneously:http://www.preskorn.com/columns/0003.html
Todd
poster:King Vultan
thread:329473
URL: http://www.dr-bob.org/babble/20040325/msgs/329527.html