Posted by douglass on March 25, 2004, at 13:04:33
I have read with great diligence the old threads of Andrew, Peter et al from the 2000 archives and have found them quite informative. I also would like to give you my knowledge and experience of taking amineptine and give a new source of amineptine shipped here in USA so you could get it in a matter of a few days as opposed to weeks when we had to go off shore for it when it was still on the market.
Here's the URL for it xxx and to get abstract medical research done on amineptine, go here xxx there is a wealth of info. on this site.
Briefly here is a one paragraph summary of it's pharmacology;Substance identification
Amineptine (7-[(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)amino]heptanoic acid) is available as either the free base (CAS 57574-09-1) or as the hydrochloride salt (CAS 30272-08-3). There are no chiral carbon atoms, therefore, no stereoisomers or racemates are possible.Similarity to known substances and effects on the central nervous system
Amineptine is a synthetic, atypical tricyclic antidepressant with central nervous system stimulating effects. It is an indirect dopamine agonist, selectively inhibiting dopamine uptake and inducing dopamine release, with additional stimulation of the adrenergic system. Its antidepressant effects are similar to other tricyclic antidepressant drugs but it has a more rapid action, is better tolerated and has little cardiovascular, analgesic or anorectic effects. It produces a similar spectrum of pharmacological effects to psychomotor stimulants in Schedule II of the 1971 Convention on Psychotropic Substances.
My past history with AD sounds much like what I've read so far from Andrew and Peter and others. I have tried most all AD and through doing my own research back in 1994 and before I found a drug made in France called "Miniaprine" which was a dopaminergic and some other actions I don't recall off hand as it's been so long. But that was my first introduction to dopamine type drugs for depression secondary to combat PTSD. It did nothing for the PTSD but it sure drove the depression back. Unfortunately I came at the end of the life of miniaprine as it was soon not lisenced for sale in France or anywhere in Europe and now I believe it's out of production all over the world. If any one knows where there is a source I would be very interested.
I then was put on tranclcypromine(parnate), an MAOI. Except for the side effects, it was the best AD to date. I found out I was anergic, anhedonic, psychomotor retardation and a severe lack of motivation. Before any drugs I was vegetatively depressed for almost 20years before I sought help.
The miniaprine got me started on a long search for dopaminergics for depression. I also got in the waning months of GHB and found that to be a most potent AD but the roller coaster ride made it impracticle to use as an ongoing AD, but the dopaminergic stimulation I got was tremendous. I could think productively,, my thoughts were so fast I couldn't keep up with them so I was using too much GHB so I cut it in half and got a better response. I was motivated, my sleep requirements were 5 hr.s/day and was motivated to do projects and got enjoyment out of them. I felt alive for the first time since I left Viet Nam(if you call living thru viet nam alive)Then it got pulled, so I tried GBL and got similar responses but soon all analogues of GHB were CI(except for research, there it was CIII)
I knew at this point in 1996 that I was a subset of depressants depleted of normal stores of Da, so my quest was to finddopmaminergics.
The parkinsons seemed a rich source, but the side effects were too much to handle. Sinemet made me nauseous ,I haven't tried pramipexole but it increases prolactin so that was out. There were a whole group likr ropinole, quinpirone, requip,sulpride, amisulpride and some others. I was ready to start my course of going down the list and giving each a trial as monotherapy to see if one would be right for me. It was also at this time I came upon xxx here I found amineptine and decided to try it. Only one place in the world that would sell it without an RX was xxx. One whole year I took 200mg daily and the efficacy stayed the same. There may have been some down regulation, but it wasn't noticeable to me. Then Argentina stopped selling it and back to searching. I found some drug stores in Greec, Spain Uraguay but all wanted RX and Dr's here can't write for an unapproved drug as the USA never did any studies with amineptine so never came up for approval.
Now there are some interested people who found a source of pharmaceutical grade amineptine by Servier of Brazil that are selling it from USA, so it onlt takes a few days to get here and is about $200/month supply. Provigil, which my Dr RXed to me, was almost $90 for 10 200mg tabs. Amineptine has no side effects at therapeutic levels and has all the positive effects you look for in an anti depressant.
If any one else out there has had experience with amineptine, I would like to hear from you and your experience on it and wher you get yours if you do buy any as I have done 2 years of intensive research and right now know of only one source.
It's amazing what one drug can do to get your life back.This drug may not be for any depressed person and may not work for you, but if your one of the ones it does work for, you can stop looking.
I would be very interested in hearing what Andrew or peter have to say if they still frequent this forum.
to happy hypomanic days
douglas
poster:douglass
thread:328237
URL: http://www.dr-bob.org/babble/20040325/msgs/328237.html