Posted by djmmm on October 19, 2003, at 20:25:34
In reply to Inderal LA, posted by SandyWeb on October 19, 2003, at 11:18:51
> Does anyone know if Inderal LA (I take 80mg dose) is a slow-release for 12-hours, or is it a slow release for 24-hours?
>
> I have been assuming that the dose is for a 24-hour period, and I take it at 8am each day. However, I experience the symptoms of my blood pressure going back up and my heart rate increasing as the day wears on.....especially in the evening and when I go to bed. The early morning is the worse, with the sensation of pounding in my legs, head, etc.
>
> If the med is only slow release for 12-hours, I guess I would need to take it twice per day?
>
> Thanks for any help!
>
> SandyWeb
>The LA (slow release version) has a HALF LIFE of 10-12 hours...which is 3x as long as the traditional verison...but if you are still experiencing problems, Talk to your doc about it.
from http://www.mentalhealth.com/drug/p30-i02.html
Inderal-LA is a special formulation of propranolol hydrochloride consisting of capsules filled with spheroids of the active drug that have a sustained-release coating.
Propranolol from Inderal-LA capsules is almost completely absorbed from the gastrointestinal tract. A large part of the absorbed drug is lost from the systemic circulation due to first-pass metabolism in the liver. The first-pass metabolism is saturable. Steady-state plasma propranolol concentrations from Inderal-LA are proportional to the dose over the range of 60 to 160 mg/day although there is considerable intersubject variation. In healthy volunteers steady state was achieved after 2 or 3 days administration of Inderal-LA.
Peak blood levels following administration of Inderal-LA capsules occur at about 6 hours and the apparent plasma half-life has been reported to be between 10 and 12 hours i.e. 2 to 3 times that of the conventional tablet formulation.
When measured at steady state over a 24-hour period the areas under the propranolol plasma concentration-time curve (AUCs) for the LA-capsules are approximately 60 to 65% of the AUCs for a comparable divided daily dose of Inderal Tablets. The lower AUCs for the Inderal-LA capsules are due to greater hepatic metabolism of propranolol because of slower absorption. Over a 24-hour period, blood levels are fairly constant for about 12 hours, then decline exponentially.
poster:djmmm
thread:270806
URL: http://www.dr-bob.org/babble/20031015/msgs/270940.html