Posted by Questionmark on June 16, 2003, at 5:11:19
In reply to Re: I'd like to know about this too, posted by linkadge on June 15, 2003, at 18:02:09
> Increasing Norepinephrine can lead to irritablility (in general Effexor causes more thant SSRIs) But I think it is linked the 5HT-2 blocking abilities. It relieves insommnia, but during the day I think activating these receptors reduces irritability.Maybe partially, but no, i'll tell you exACTly what this is from-- the antihistaminic effects. Ever since i can remember (about a decade), whenever i would take any psychoactive antihistamine, including Remeron and diphenhydramine (Benadryl) and etc., i would get SO FREAKING IRRITABLE. It's weird, but it's definitely true. i think it's like you're just so damn drowsy and lethargic that when you have to do the slIGHtest extra thing, or say the slightest extra things to people, it just drives you mad (like "AH shut UP! Don't make me move; don't make me talk).
On that note, i really think the antihistaminic effects of Remeron are highly overlooked by the psychiatric, pharm., etc communities. Yeah they say it's responsible for "some" weight gain and appetite increase (which i dont personally mind at all), but what about the other results of histamine antagonism? i also always noticed that on any antihistamine i'd always be MUCH more depressed-- especially the next day. Now you observe those "Organon conferences" (about the wonders of Remeron basically-- it's on the internet), and you will find all sorts of praise for Remeron's lack of side effects and its antidepressant pharmacological effects (basically like "and the norepinephrine potentiation combined with the serotonin potentiation should have highly effective antidepressant properties" or whatever), but does it MENtion that the strong-as-heck antihistaminic properties might actually AGGRAVATE depression considerably, or can turn one into a raging idiotic wordless baffoon?? Noooooooo, of course not, they're not gonna spend money on finding that s**t out. That stuff just makes me angry.
i do believe, however, that Remeron can still definitely be a good antidepressant and what not, of course. But i just wish they would say that it might also do [this & this & this] and even make you more depressed, etc until maybe the you get tolerance to the anti-H effects enough. Same with other drugs-- same concept. The patients are left in ignorance.
poster:Questionmark
thread:234154
URL: http://www.dr-bob.org/babble/20030614/msgs/234257.html