Posted by utopizen on April 26, 2003, at 11:41:03
In reply to Re: Xyrem use restricted, not severely, posted by Caleb462 on April 26, 2003, at 0:58:37
> From what I understand, GHB (Xyrem) inhibits the release of dopamine for a period of time. This causes dopamine to build up in the neuron, and then upon waking, large amounts of dopamine are released - inducing increased wakefulness, motivation, etc.
> There may be other mechanisms at work too, I dunno.Actually, the dopamine effects are perhaps the least understood aspect to it. The more obvious, and researched, effect of GHB is its effect on growth hormone levels and sleep architecture. If you've got odd sleep architecture, you're going to require more than 8 hours, and be tired anyway. It's called Excessive Daytime Sleepiness, and Xyrem is testing in Phase II for this indication.
People who reported being tired after 9 1/2 hours each night claim GHB let them feel alert on just 5 or 6 hours each day. It definitely makes sleep more efficient by deepening restorative sleep.
poster:utopizen
thread:222298
URL: http://www.dr-bob.org/babble/20030423/msgs/222572.html