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Re: Serzone and SSRI

Posted by noa on February 7, 2003, at 11:13:48

In reply to Re: cyproheptadine for SSRI-induced anorgasmia? » fairnymph, posted by one_little_victory on February 7, 2003, at 2:12:38

I also take Serzone as well as Effexor. The serzone was added to do two main things--add antidepressant effect because although effexor has a good AD effect for me, I could not tolerate higher doses. The second thing is to counteract some of the effexor overactivation, I think by blocking 5HT2 receptors. Too much serotonin stimulation of these receptors I think was causing me to have insomnia, muscle twitching, general restlessness, restless legs, etc.

As far as how it helps with anorgasmia, it helps some, but sexual sensation is more limited and requires more focused effort, and orgasms are still hard to achieve. At night, long after taking effexor, and after the serzone has settled in, it is a little better, but still the experience is more restricted and orgasms are what I call fragmented.

When I used to take ritalin, there was a short window of time when sex/orgasm was a bit better, especially if I took the ritalin and waited on the effexor. Adderall does not do the same thing.


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