Posted by utopizen on February 2, 2003, at 22:05:35
In reply to Re: Adderall - what is the action of amphetamines? » btnd, posted by Shawn. T. on February 2, 2003, at 21:38:54
Considering the widely abused rate of the amphetamines during the 60's and 70's, the rate of consquences stemming from such abuse would have been seen by now.
In one article written in '68 for the Atlantic, anecdotes of entire pill parties where it was commonplace to take 300mg-500mg of amphetamines at a time, often of the methamphetamine pharmaceutical Desoxyn combined with Nembutal, called Desbutal.
These people thought amphetamines had nearly made sleep obsolete, and would go days without it on a regular basis.
It's not just that rats have different neurochemistry. The biggest problem is trying to find equivelent dosing. Remember that for ritalin trials on pediatric uses, rat pups are required. And also remember that Ritalin and the amphetamines do not have weight coorelations to their dosing. An obsese adult may require less Ritalin than a 40 lb. 4 yr. old. So exactly how do you determine what a similar effect will occur from a dose given to a rat pup will be? The answer is you never will know, in the same reason that it remains impossible to extrapolate findings BETWEEN humans much less between entire species.
poster:utopizen
thread:138755
URL: http://www.dr-bob.org/babble/20030130/msgs/139026.html