Posted by stjames on February 1, 2003, at 17:21:56
In reply to Re: Adderall - what is the action of amphetamines?, posted by utopizen on February 1, 2003, at 16:15:49
> > Ok I'm confused, most of the studies on pubmed show that amphetamine (or methamphetamine) is neurotoxic. So how can Adderall/Dexedrine or any other amphetamine-based drug be prescribed and used even by children? Is there a different action of amphetamine in small doses (up to 40 mg)? What about neurotoxicity? I'm mostly interested whether 50 mg amphetamine/daily is neurotoxic or not. I appreciate your input.
At high levels almost everything is toxic. The tests that showed changes in neurology were at very high dose. Changes are not, per se, neurotoxicity. We have 90 years history of people taking amphetamines, so we would of seen neurotoxicity by this point, if it were there.Given how significant mental illness can be and the degree of change meds can bring, reporting changes to neurology because of these meds seems
a "well, duh". Since we are no where near being able to classify what most to the lifetime structure is of most parts of neurology, I think it is just as reasonable to infer the change in mental illness, while on meds, to the change in neurological structure. We do know some biochemical markers that are always assoc. with
neurotoxicity and they are not seen in amphetamine
use.
poster:stjames
thread:138755
URL: http://www.dr-bob.org/babble/20030130/msgs/138783.html