Posted by Mitch on November 6, 2001, at 13:48:41
In reply to Re: Why Is Zoloft No1, posted by SLS on November 6, 2001, at 12:54:51
> For what it's worth, Zoloft produces the most dopamine reuptake inhibition of the SSRIs, although its magnitude is considered by most as being irrelevant at therapeutic dosages. However, this always begs me to ask the question: "How does one determine the amount of anything that can be neglected?"
> - ScottHi Scott,
That is interesting about the dopamine reuptake inhibition. When I saw that on my pdoc's "receptor affinity profiles for SSRi's" it found that somewhat peculiar. It is interesting that I get the least amount of dystonia from Zoloft than any of the other SSRI's. There's another thing, too. The primary drug sertraline has a half-life of about 26 hrs. Well, it's primary metabolite desmethyl-sertraline has a half-life of 2-3 *days*. It's not supposed to be *active* but that makes me a little puzzled. It seems when I take a dose I get a little drowsy the first few hours (kind of like Celexa, i.e.), but then later in the day I seem to become very alert. When I am up the next day just before my dose I feel very attentive and alert. I wonder if desmethyl-sertraline has more of a dopaminergic or noradrenergic effect they aren't telling us about?
Mitch
poster:Mitch
thread:83199
URL: http://www.dr-bob.org/babble/20011104/msgs/83349.html